Molecular editing

Our group has recently started to expand the toolbox for molecular editing reactions. These involve modifying densely functionalized motifs by inserting, deleting, or exchanging atoms or small molecular fragments.

Selected publications:

• Late-Stage Molecular Editing Enabled by Ketone Chain-Walking Isomerization (JACS 2023 external pagedoicall_made)
  
• Skeletal metalation of lactams through a carbonyl-to-nickel-exchange logic (Nat. Commun. 2023 external pagedoicall_made)
  
• Nitrogen atom insertion into indenes to access isoquinolines (Chem. Sci. 2023 external pagedoicall_made)
  
• Late-​stage diversification of indole skeletons through nitrogen atom insertion (Science 2022 external pagedoicall_made)